Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields. Here, the authors report the engineering of self-cyclizing ‘autocyclase’ proteins to generate macrocyclic peptides and proteins with favorable reaction kinetics for suppressing polymerization.
- Xinying Jia
- Yanni K.-Y. Chin
- Mehdi Mobli
