Fluorine-18 containing molecules are important for PET imaging, but due to the short half-life it is necessary to develop rapid methods for its introduction. Here, the authors use spirocyclic iodine(III) precursors, allowing direct 18F labelling of highly functionalized non-activated arenes and PET radiopharmaceuticals.
- Benjamin H. Rotstein
- Nickeisha A. Stephenson
- Steven H. Liang
