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Showing 1–11 of 11 results
Advanced filters: Author: Nico Strohmeyer Clear advanced filters

  • Whether and how cells measure and regulate their adhesion in response to the extracellular matrix area is unknown. Here, the authors show that cells adhering to restricted matrix protein areas exhibit a spatially enhanced adhesion state with much higher force per unit area compared to cells on larger areas.

    • Xiaole Wang
    • Pengli Wang
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Adopting a round cell morphology before mitosis is crucial. Here, the authors show that in mitosis integrins binding to ligands do not engage the actomyosin cortex, which curbs cell-extracellular matrix adhesion, though β1 integrins are rewired to synergize with cadherins in mitotic cell-cell adhesion.

    • Maximilian Huber
    • Javier Casares-Arias
    • Nico Strohmeyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

    • Franziska L. Lampart
    • Roman Vetter
    • Dagmar Iber
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 279-288

  • There is increasing interest in measuring the mechanical properties of living cells. Here, the authors develop a method to simultaneously measure the cell mass and two parameters related to its natural oscillation or resonance frequencies.

    • Sophie Herzog
    • Gotthold Fläschner
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Here, the authors show how binding of talin and kindlin to the β-integrin cytoplasmic tail increases talin and decreases kindlin affinity toward it, providing insights into mechanisms of integrin activation.

    • Jonas Aretz
    • Masood Aziz
    • Reinhard Fässler
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1913-1924

  • While rheology studies have contributed to the understanding of the viscoelastic properties of living cells, the use of higher frequencies promises elucidate the link between cellular and molecular properties. Here authors introduce a rheological assay that measures the cell mechanical response across a continuous frequency range ≈ 1 – 40 kHz.

    • Gotthold Fläschner
    • Cosmin I. Roman
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (<120 s) remain unclear. Here, the authors show that αv-class integrins bind fibronectin faster than α5β1 integrins and subsequently signal to α5ß1 integrins to strengthen the adhesion.

    • Mitasha Bharadwaj
    • Nico Strohmeyer
    • Daniel J. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Atomic force microscopy-based force spectroscopy can probe the strength and dynamics of cell adhesion to understand how physical forces influence cellular function, physiology and disease. Here, Dufrêne and colleagues discuss the ability of this technology to work as an ultra-sensitive force sensor to study the adhesion and elasticity of complex biological systems including viruses, bacteria, yeasts and mammalian cells.

    • Albertus Viljoen
    • Marion Mathelié-Guinlet
    • Yves F. Dufrêne
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-24