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Showing 251–300 of 527 results
Advanced filters: Author: Nicola McCarthy Clear advanced filters

  • Hyperactive AID can result in widespread genomic damage and lymphoma.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 5

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Immunology
    Volume: 8, P: 242-243

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 461

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 4, P: 924

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 6, P: 657

  • CCCTC-binding factor (CTCF) is involved in the regulation of the tumour suppressor p53 through binding to theTP53 antisense transcript WRAP53.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 295

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 251

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 5, P: 336

  • Joan Massagué and colleagues have found that epigenetic changes contribute to metastasis in clear-cell renal-cell carcinomas in which the tumour suppressor gene von Hippel–Lindau (VHL) is inactivated.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 78

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 151

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 7, P: 684-685

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 7, P: 909

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 5, P: 84

  • Reactive aldehydes generated by metabolism may contribute to the pathogenesis of Fanconi anaemia.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 734

  • The extent of tumour heterogeneity has been explored in a paper recently published in theNew England Journal of Medicine.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 317

  • WNT signalling has been linked to the transcriptional coactivators TAZ and YAP1.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 81

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 8, P: 489

  • A paper published inSciencedelves further into the mechanisms through which mutations in isocitrate dehydrogenase contribute to leukaemogenesis.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 220-221

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 769

  • A subset of melanoma cells express high levels of PGC1α, which alters their metabolic phenotype compared with melanoma cells that do not express PGC1α.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 222

  • In order to proliferate, cells with oncogenic mutations might first need to escape the restrictions of the epithelial environment.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 153

  • A paper published inMolecular Cell indicates that the production of ketones can promote the BRAFV600E–MEK–ERK oncogenic pathway and identifies a potential Achilles' heel.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 15, P: 455

  • This paper suggests that recurrent regions of somatic hemizygosity might exist in tumours because they enable a reduction in the expression levels of genes that restrict cell proliferation and survival, and minimize the loss of genes that are essential for cell survival.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 451

  • ARTS, an inhibitor of XIAP, is required for apoptosis in haematopoietic stem and progenitor cells, and loss of ARTS can promote tumour development.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 816-817

  • Identification of a small transcription factor network that is responsible for the mesenchymal behaviour of glioma cells.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 80-81

  • A paper inCell Stem Cellthat uses lineage tracing in the pituitary shows that, although mutations in a subpopulation of stem cells can induce tumour formation, the tumour cells do not arise from the mutated stem cells.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 824-825

  • Susan Clark and colleagues have found evidence in cancer cells that epigenetic changes can occur over long stretches of chromatin, leading to increased gene expression.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 76

  • A paper by Dmitry Bulavin and colleagues shows that WIP1 is involved in regulating DNA methylation-mediated silencing of heterochromatin and might contribute to C-to-T substitutions and mutation load in breast cancers.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 823

  • The cancer stem cell marker CD44 is a target of the tumour suppressive microRNA, miR-34a.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 11, P: 156

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 9, P: 459

  • Two papers have found that high-grade bladder cancer can be spilt into several subtypes, including luminal and basal subtypes, which match these subtypes in breast cancer.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 214-215

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 4, P: 574

  • This paper shows that apoptosis induced by cisplatin relies on signals that involve MDM2, MDMX, p53, NOXA and TAB1.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 682-683

  • Mitochondrial defects in cells expressing oncogenic RASV12can induce surrounding cells to proliferate owing to effects on the Hippo pathway.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 734

  • Mutant p53 promotes cell migration and invasion through integrin recycling.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 81

  • Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

    • Anne E. Justice
    • Thomas W. Winkler
    • L Adrienne Cupples
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 5, P: 243

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 7, P: 815

  • A paper published inCancer Discovery shows that H3 G34R or G34V mutations result in the altered binding of proteins that recognize trimethylated H3K36. This results in a gene expression signature that is more commonly seen in the developing forebrain and that is associated with increased MYCNtranscription.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 382-383

  • Two papers published inSciencedescribe small molecules that inhibit mutant forms of IDH1 and IDH2.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 383

  • The loss of a component of the transcriptional mediator complex MED12 is implicated in resistance to a number of targeted and standard chemotherapeutic agents.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 7

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 6, P: 418-419

  • A new mouse model of adoptive cell transfer for the treatment of melanoma indicates that dedifferentiation of melanoma cells, driven by an inflammatory response, might have a role in resistance.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 12, P: 739

  • A new method allows the identification of rare mutations in mitochondrial DNA that differ between normal and cancer cells.

    • Nicola McCarthy
    Research Highlights
    Nature Reviews Cancer
    Volume: 10, P: 235