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Showing 1–8 of 8 results
Advanced filters: Author: Nicola Ternette Clear advanced filters

  • Detection of neoepitopes from tumours is time consuming and requires the integration of genomic and/or RNA sequencing expression data. Here, the authors propose a machine learning method to enable direct identification of additional, tumour-specific sequences using mass spectrometry through integration of de novo peptide sequencing scores, MHC class I binding prediction, and peptide retention time prediction.

    • Hanqing Liao
    • Carolina Barra
    • Nicola Ternette
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The use of bispecific antibodies to target tumour-specific epitopes presented by MHC molecules in tumour tissue is a promising avenue for cancer immunotherapy. Here the authors use a mass-spectrometry guided analysis to identify off-target MHC-peptide complexes that bind to TCR-like antibodies next to the target peptide, enabling a novel approach to monitoring of antibody specificity during clinical maturation and development.

    • Estelle Marrer-Berger
    • Annalisa Nicastri
    • Nicola Ternette
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Interferon-α (IFN-α) is linked to type 1 diabetes (T1D), but how IFN-α impacts auto-antigen presentation is still unclear. Here the authors compare resting and IFN-α-treated islet β cells in vitro to find IFN-α inducing increased HLA-B expression, presentation of alternative epitopes, and activation of HLA-B-restricted T cells, thereby serving clues for T1D onset.

    • Alexia Carré
    • Fatoumata Samassa
    • Roberto Mallone
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses when delivered as vaccine vectors in mice.

    • Wojciech Barczak
    • Simon M. Carr
    • Nicholas B. La Thangue
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.

    • Sunil Kumar Saini
    • Andreas Due Ørskov
    • Sine Reker Hadrup
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Peptide antigens are bound to molecules encoded by the major histocompatibility complex (MHC) and presented on the cell surface as targets for T lymphocytes. This protocol uses nUPLC–MS/MS to identify MHC-bound peptides from cell lines and tissues.

    • Anthony W. Purcell
    • Sri H. Ramarathinam
    • Nicola Ternette
    Protocols
    Nature Protocols
    Volume: 14, P: 1687-1707