Amyloid fibrils grow through the recruitment of soluble monomer to the fibril end that propagates the fibril structure. Here the transition state, the rate-limiting conformation, of such a reaction has been characterized by Φ-value analysis. An energy landscape model has been developed and fibril growth rates predicted from first principles.
- Jacob Aunstrup Larsen
- Abigail Barclay
- Alexander K. Buell
