In asthmatic individuals, a small subset of CD4+ T cells express the chemokine receptor CX3CR1, whose ligand is CX3CL1. In this issue, Mionnet et al. report that this chemokine-receptor pair is important in experimental asthma, conferring a survival advantage on CX3CR1-expressing CD4+ T cells, and show that blocking CX3CR1 signaling has therapeutic benefit in mice.
- Cyrille Mionnet
- Vanessa Buatois
- Valerie Julia
