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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Alzheimer’s disease is often considered a disease of neurons. This study reveals that astrocytes are also impaired by the disease and that these cells contribute more to memory deterioration than previously thought.

Kevin Richetin
Pascal Steullet
Nicole Déglon
Research09 Nov 2020
Nature Neuroscience

Volume: 23, P: 1567-1579
Small molecule induced STING degradation facilitated by the HECT ligase HERC4

In this paper, Mutlu et al. identifies a STING degrader, AK59, which inhibits downstream cGAS/STING activity through STING degradation employing a HECT-domain E3 ligase HERC4 and proteasomal ubiquitination pathway.

Merve Mutlu
Isabel Schmidt
Danilo Guerini
ResearchOpen Access29 May 2024
Nature Communications

Volume: 15, P: 1-16

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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Small molecule induced STING degradation facilitated by the HECT ligase HERC4

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