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Advanced filters: Author: Nicolas Sluis-Cremer Clear advanced filters

Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription

The intermediate states occurring during nucleotide addition by HIV-1 RT remain unclear. Here, authors use cryo-EM to capture five unique states that show how a mobile catalytic Mg²⁺ drives phosphodiester bond formation.

Sandra Vergara
Xiaohong Zhou
Guillermo Calero
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4⁺ T cells

Sanyal et al. report a new and rapid assay for measuring replication-competent HIV-1 in CD4⁺ T cells.

Anwesha Sanyal
Robbie B Mailliard
Phalguni Gupta
Research29 May 2017
Nature Medicine

Volume: 23, P: 885-889

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Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription

Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells

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Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4⁺ T cells