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Showing 1–2 of 2 results
Advanced filters: Author: Nicolas Stankovic-Valentin Clear advanced filters

  • FAT10 is an ubiquitin-like modifier that targets proteins to proteasomal degradation. Here, the authors show that FAT10 also regulates SUMO activation in vitro and in cells, providing evidence for functional crosstalk between two ubiquitin-like modifiers.

    • Annette Aichem
    • Carolin Sailer
    • Marcus Groettrup
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The bicyclic disulfide–containing compound thiolutin has broad antimicrobial activity and targets the essential proteasomal deubiquitinase Rpn11 and other metalloproteases, leading to inhibition of enzymatic activity through a mechanism involving zinc chelation.

    • Linda Lauinger
    • Jing Li
    • Axel Diernfellner
    Research
    Nature Chemical Biology
    Volume: 13, P: 709-714