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Showing 1–5 of 5 results
Advanced filters: Author: Nicole A. de Weerd Clear advanced filters

  • Interferon-ε is a tumour suppressor expressed in the epithelial cell of origin of ovarian cancer, which it restricts by direct action on tumour cells and especially by activation of anti-tumour immunity.

    • Zoe R. C. Marks
    • Nicole K. Campbell
    • Paul J. Hertzog
    Research
    Nature
    Volume: 620, P: 1063-1070

  • Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastatic spread. These seemingly opposing functions are a result of the requirement of STAT3 for stimulator of interferon genes–interferon signaling in metastasis and the authors show how it can be targeted in mice.

    • Aleks C. Guanizo
    • Quinton Luong
    • Daniel J. Gough
    Research
    Nature Immunology
    Volume: 25, P: 2259-2269

  • The authors identify Irf7 and associated interferon signaling as an important factor suppressing bone metastasis of breast cancers. Irf7 is lost in experimental metastasis and human bone metastastic tissue, and this fosters an immunosuppressive environment that facilitates metastasis. Manipulating this innate immune signaling pathway emerging from tumor cells by interferon administration had beneficial effects in mouse models by reducing bone metastasis and increasing survival time.

    • Bradley N Bidwell
    • Clare Y Slaney
    • Belinda S Parker
    Research
    Nature Medicine
    Volume: 18, P: 1224-1231

  • Type I interferons regulate immune responses by signaling via heterodimeric IFNAR1-IFNAR2 complexes. Hertzog and colleagues reveal a unique IFN-β–IFNAR1 signaling complex that is IFNAR2-independent and modulates expression of a distinct set of interferon-inducible genes.

    • Nicole A de Weerd
    • Julian P Vivian
    • Paul J Hertzog
    Research
    Nature Immunology
    Volume: 14, P: 901-907