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Showing 1–4 of 4 results

Advanced filters: Author: Nicole Dobbs Clear advanced filters

Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Microbial DNA is recognized by the cGAS-STING pathway, which leads to a type I interferon response. Here authors show that a basal flux of interferon activation could also be triggered by interference with STING trafficking from the Golgi apparatus to the lysosomes.

Xintao Tu
Ting-Ting Chu
Nan Yan
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-16
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response

Mammalian glycans have a role in host immunity but little is known about how they activate the host response in the context of autoimmune diseases. Here, the authors identify Manβ1-4GlcNAc as a novel innate immune modulator associated with chronic autoimmune diseases.

Charles S. Fermaintt
Kanae Sano
Nan Yan
ResearchOpen Access30 May 2019
Nature Communications

Volume: 10, P: 1-12
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

The protein STING has an essential function in intracellular DNA sensing, but how it is regulated under steady state is unclear. Yan and colleagues demonstrate that the protein TOLLIP stabilizes steady-state STING and facilitates its signaling.

Vladislav Pokatayev
Kun Yang
Nan Yan
Research13 Jan 2020
Nature Immunology

Volume: 21, P: 158-167
Sch 213766, A Novel Chemokine Receptor CCR-5 Inhibitor from Chaetomium globosum

Shu-Wei Yang
Ronald Mierzwa
Min Chu
Research01 Aug 2007
The Journal of Antibiotics

Volume: 60, P: 524-528