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Advanced filters: Author: Nicole Espy Clear advanced filters

  • HIV-1 binds host CD4+ T cells via its gp120 envelope glycoprotein that undergoes changes to allow ‘opening’ of the envelope trimer, exposure of gp41 and binding to the CCR5 co-receptor. Compound 18A inhibits HIV-1 infection by blocking some of these conformational changes.

    • Alon Herschhorn
    • Christopher Gu
    • Joseph G Sodroski
    Research
    Nature Chemical Biology
    Volume: 10, P: 845-852