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Showing 1–5 of 5 results
Advanced filters: Author: Nicole Messerschmidt Clear advanced filters

  • Serial femtosecond X-ray crystallography permits the use of very small protein crystals; however, a continuous flow of sample is required. Weierstall et al. design and demonstrate an injector system that can supply microcrystals in the lipidic cubic phase, dramatically reducing the quantities of protein required.

    • Uwe Weierstall
    • Daniel James
    • Vadim Cherezov
    Research
    Nature Communications
    Volume: 5, P: 1-6

  • Diacylglycerol kinase is a small bacterial membrane-bound trimer that catalyses diacylglycerol conversion to phosphatidic acid. Here, the authors solve the crystal structure of the kinase bound to a lipid substrate and an ATP analogue, and show that the active site arose through convergent evolution.

    • Dianfan Li
    • Phillip J. Stansfeld
    • Martin Caffrey
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • G protein-coupled receptors are a large family of signalling proteins that mediate cellular responses primarily via G proteins or arrestins, and they are targets of one-third of the current clinically used drugs; here, an active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin-1 is determined, revealing unique structural features that may constitute essential elements for arrestin-biased signalling.

    • Yanyong Kang
    • X. Edward Zhou
    • H. Eric Xu
    Research
    Nature
    Volume: 523, P: 561-567