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Showing 1–15 of 15 results
Advanced filters: Author: Nicole R. Gay Clear advanced filters

  • Hematopoietic stem cells (HSCs) differentiate into multiple lineages, with such capacity impacted by aging. Here the authors identify Kitlo HSCs as a functionally distinct population that exhibits distinct lymphoid-primed chromatin landscapes, which drive enhanced lymphoid reconstitution capacity, and is altered in aged hosts.

    • Harold K. Elias
    • Sneha Mitra
    • Marcel R. M. van den Brink
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastatic spread. These seemingly opposing functions are a result of the requirement of STAT3 for stimulator of interferon genes–interferon signaling in metastasis and the authors show how it can be targeted in mice.

    • Aleks C. Guanizo
    • Quinton Luong
    • Daniel J. Gough
    Research
    Nature Immunology
    Volume: 25, P: 2259-2269

  • Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

    • David Amar
    • Nicole R. Gay
    • Elena Volpi
    ResearchOpen Access
    Nature
    Volume: 629, P: 174-183

  • It is known that exercise influences many human traits, but not which tissues and genes are most important. This study connects transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium with human data to identify traits with similar tissue specific gene expression signatures to exercise.

    • Nikolai G. Vetr
    • Nicole R. Gay
    • Stephen B. Montgomery
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • CD4+ T cells recognising shared susceptibility epitope (SE) encoded HLA-DRB1 presenting citrullinated self-peptides are implicated in rheumatoid arthritis. Here the authors characterise the T cell receptor repertoire and structure during recognition of different citrullinated self-epitopes in HLA-DR4 transgenic mice and ACPA + RA patients.

    • Tiing Jen Loh
    • Jia Jia Lim
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Racism thrives in geoscience. We present an antiracism plan to support the recruitment, retention and success of Black, Indigenous, and other people of color in geoscience. Our action plan can be adapted by any organization to remove barriers to participation for all marginalized geoscientists.

    • Hendratta N. Ali
    • Sarah L. Sheffield
    • Blair Schneider
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-6

  • Mielke et al. perform a multi-assay analysis of humoral and adaptive cellular responses to SARS-CoV-2 in people with HIV compared to people without HIV. Using supervised machine learning tools and network analysis, the authors find differences in the immune profile and anti-endemic coronavirus immune response between these two populations.

    • Dieter Mielke
    • Shuying Sue Li
    • Guido Ferrari
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-15

  • Currently Central Africa is experiencing multiple large concurrent mpox outbreaks spreading across several nations and at-risk populations via multiple transmission modes. This current surge of cases, framed in the context of the 2022 global outbreak, is challenging legacy understandings of mpox. Here, we consider how the political, economic, and public health conditions of the Democratic Republic of the Congo have influenced the recorded epidemiology of mpox and how, given this context, current vaccine and outbreak response can be crafted for greatest impact.

    • Megan Halbrook
    • Jean Claude Makangara-Cigolo
    • Jason Kindrachuk
    Comments & OpinionOpen Access
    npj Viruses
    Volume: 2, P: 1-4