Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–1 of 1 results
Advanced filters: Author: Niklas Kehl Clear advanced filters
  • Bioisosteric replacement is vital in drug discovery; however, substituting core ring structures is challenging. Now, a strategy that converts pyridines into benzonitriles, via N-oxidation, photochemical deconstruction and Diels–Alder cycloaddition reactions, is reported. The conversion of pyridines to benzonitriles, which mimic the properties of pyridines, enables modular late-stage-diversification of drug molecules.

    • Reyhan Güdük
    • Niklas Kehl
    • Daniele Leonori
    ResearchOpen Access
    Nature Synthesis
    Volume: 4, P: 848-858