A positive feedback loop which results in localized accumulation of the small GTPase Cdc42 generates cell polarity in budding yeast; however, such loops are inherently susceptible to noise. Here the authors demonstrate how two pathways that mediate Cdc42 recycling work together to ensure the robustness of symmetry breaking.
- Tina Freisinger
- Ben Klünder
- Roland Wedlich-Söldner
