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Showing 1–2 of 2 results
Advanced filters: Author: Nikolaos Demiris Clear advanced filters

  • Toxicities limit combination of PARP inhibitors (PARPi) and chemotherapy in patients with germline BRCA1 and BRCA2 pathogenic variant (gBRCAm) breast cancer. Here, the authors report a preclinical study followed by a randomised phase II/III clinical trial investigating the addition of a gap between chemotherapy (carboplatin and paclitaxel) and PARPi (olaparib), in patients with early gBRCAm breast cancer.

    • Jean E. Abraham
    • Lenka Oplustil O’Connor
    • Helena M. Earl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A study details the results of the PARTNER trial, a prospective, randomized controlled trial of the use of neoadjuvant olaparib with carboplatin–paclitaxel chemotherapy in patients with triple-negative breast cancer who were germline BRCA1 and BRCA2 wild type.

    • Jean E. Abraham
    • Karen Pinilla
    • Helena M. Earl
    ResearchOpen Access
    Nature
    Volume: 629, P: 1142-1148