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Showing 1–6 of 6 results
Advanced filters: Author: Nikolaos Kaplaneris Clear advanced filters

  • Sulfur-containing scaffolds originating from small alkyl fragments play a crucial role in various pharmaceuticals, agrochemicals, and materials, but their synthesis presents significant challenges. Herein, the authors report the photocatalytic conversion of C(sp3)–H bonds originating from lightweight alkanes into alkyl sulfinates, employing SO2.

    • Dmitrii Nagornîi
    • Fabian Raymenants
    • Timothy Noël
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • Bioorthogonal diversification of peptides is generally dependent on impractical prefunctionalization methods. Here, the authors develop a manganese(I)-catalyzed C–H fluorescent labeling with BODIPY probes, which enables the development of activatable fluorophores to image cell function.

    • Nikolaos Kaplaneris
    • Jongwoo Son
    • Lutz Ackermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Unlike the more common C–H functionalization, methods for the functionalization of C–C bonds are scarce. Here, Ackermann and co-workers show that an inexpensive manganese catalyst is capable of selectively activating C–C bonds for alkylations, alkenylations, and allylations in water.

    • Hui Wang
    • Isaac Choi
    • Lutz Ackermann
    Research
    Nature Catalysis
    Volume: 1, P: 993-1001

  • Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis.

    • Alexandra Schischko
    • Nikolaos Kaplaneris
    • Lutz Ackermann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • This Primer provides an overview of the best practices for C–H activation as well as key advances in asymmetric, photoinduced and electrocatalytic-mediated catalysis for this synthetic platform. An overview of how C–H activation facilitates the synthesis of molecules such as structurally complex (bio)polymers and drugs is provided along with the current challenges and priorities for the next decade.

    • Torben Rogge
    • Nikolaos Kaplaneris
    • Lutz Ackermann
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-31

  • Late-stage C–H functionalization of complex molecules has emerged as a powerful tool in drug discovery. This Review classifies significant examples by reaction manifold and assesses the benefits and challenges of each approach. Avenues for future improvements of this fast-expanding field are proposed.

    • Lucas Guillemard
    • Nikolaos Kaplaneris
    • Magnus J. Johansson
    Reviews
    Nature Reviews Chemistry
    Volume: 5, P: 522-545