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Showing 1–5 of 5 results
Advanced filters: Author: Nikolaos Volakakis Clear advanced filters

  • What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-clinical rat model for Parkinson’s disease and identify perivascular-like cells.

    • Katarína Tiklová
    • Sara Nolbrant
    • Malin Parmar
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neurons expressing the transcription factor Pitx3 (broad mDA neuronal marker) to identify and characterize seven neuron subgroups divided in two major branches of developing Pitx3-expressing neurons.

    • Katarína Tiklová
    • Åsa K. Björklund
    • Thomas Perlmann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Parkinson disease (PD) pathogenesis involves dysfunction and eventual death of midbrain dopaminergic neurons. Emerging evidence points to a role for the transcription factor NURR1 in this process. In this Review, the authors describe findings from animal and human studies that support this concept, outline possible underlying mechanisms involving oxidative stress and interaction with α-synuclein, and highlight the potential of NURR1 as a therapeutic target.

    • Mickael Decressac
    • Nikolaos Volakakis
    • Thomas Perlmann
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 629-636

  • This study establishes a key role for the developmental transcription factors Lmx1a/b in the maintenance of midbrain dopamine neurons. The authors show that postmitotic ablation of Lmx1b in mice leads to cellular and functional abnormalities resembling Parkinson's disease, most notably in a dysfunction in the autophagic-lysosomal pathway that results in abnormal dopaminergic synaptic connections and neuronal degeneration.

    • Ariadna Laguna
    • Nicoletta Schintu
    • Thomas Perlmann
    Research
    Nature Neuroscience
    Volume: 18, P: 826-835