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Showing 1–4 of 4 results
Advanced filters: Author: Nikolay A. Aleksashin Clear advanced filters

  • Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S rRNA as an independent molecule is based on its role in the dynamic process of ribosome biogenesis.

    • Shijie Huang
    • Nikolay A. Aleksashin
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.

    • Nikolay A. Aleksashin
    • Margus Leppik
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Ribosome engineering is an emerging powerful approach for synthetic protein synthesis. Here the authors invert the Ribo-T system, using the engineered ribosome to translate the proteome while the native ribosome translates specific mRNA.

    • Nikolay A. Aleksashin
    • Teresa Szal
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11