Regulatory T cells use a distinct metabolism to exert their regulatory function. Tsokos and colleagues show that the phosphatase PP2A suppresses the metabolic-checkpoint kinase complex mTORC1 in these cells and is necessary for their function. PP2A activity is regulated by the cellular abundance of ceramide via a transcription factor Foxp3–dependent feedback mechanism.
- Sokratis A Apostolidis
- Noé Rodríguez-Rodríguez
- George C Tsokos
