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Showing 1–6 of 6 results
Advanced filters: Author: Nils Handler Clear advanced filters

  • Optimization of biological networks is often limited by wet lab labor and cost, and the lack of convenient computational tools. Here, aimed at democratization and standardization, the authors describe METIS, a modular and versatile active machine learning workflow with a simple online interface for the optimization of biological target functions with minimal experimental datasets.

    • Amir Pandi
    • Christoph Diehl
    • Tobias J. Erb
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.

    • Yu Imai
    • Kirsten J. Meyer
    • Kim Lewis
    Research
    Nature
    Volume: 576, P: 459-464

  • A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

    • Markus K Muellner
    • Iris Z Uras
    • Sebastian M B Nijman
    Research
    Nature Chemical Biology
    Volume: 7, P: 787-793