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Showing 1–3 of 3 results
Advanced filters: Author: Nina LoGrande Clear advanced filters

  • Human cervical mucosa and its interactions with the microbiome play a central role in female reproductive tract health and disease. Here, the authors develop physiological models of the human cervix using Organ-on-a-Chip technology that produce mucus, and respond to hormonal, environmental, and microbial cues similar to the living cervix.

    • Zohreh Izadifar
    • Justin Cotton
    • Donald E. Ingber
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • A human intestine-on-a-chip lined by intestinal epithelium derived from patients with environmental enteric dysfunction and cultured in nutrient-deficient medium recapitulates essential features of intestinal dysfunction associated with the disease.

    • Amir Bein
    • Cicely W. Fadel
    • Donald E. Ingber
    ResearchOpen Access
    Nature Biomedical Engineering
    Volume: 6, P: 1236-1247

  • Studying human physiology and pathophysiology in preclinical animal models has drawbacks. Developments in organ-on-a-chip (organ chip) technology have opened up new ways to model human intestinal physiology. This Review discusses intestinal organ chips as disease models and preclinical tools and their potential for personalized medicine.

    • Alican Özkan
    • Nina Teresa LoGrande
    • Donald E. Ingber
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 21, P: 751-773