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Advanced filters: Author: Ninghe Sun Clear advanced filters

Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function

Performing a CRISPR–Cas9 screen in aged mice, Sun and colleagues identify clusterin as a driver of myeloid-biased hematopoietic stem cell differentiation in aging, through regulation of mitochondrial function via a Mnf2-OXPHOS-p38-Cebpb regulatory axis.

Ninghe Sun
Chun-Hsin Lin
Yi Zhang
ResearchOpen Access30 Jun 2025
Nature Aging

Volume: 5, P: 1510-1527
Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment

Chen et al. employ multiple approaches to show that ETV2 recruits the transcriptional repressor REST, facilitating mesoderm-to-endothelial cell specification, while simultaneously preventing iPS cell-derived mesodermal stem cells from differentiating into alternative lineages.

Danyang Chen
Xiaonuo Fan
William T. Pu
Research10 Jun 2025
Nature Cardiovascular Research

Volume: 4, P: 689-709
Transcriptome of Porcine PBMCs over Two Generations Reveals Key Genes and Pathways Associated with Variable Antibody Responses post PRRSV Vaccination

Ting Yang
Fengxia Zhang
Ying Yu
ResearchOpen Access06 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9

Lupeng Ye
Chengkun Wang
Feng Han
ResearchOpen Access24 Jul 2018
Cell Discovery

Volume: 4, P: 1-12

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