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Showing 1–3 of 3 results

Advanced filters: Author: Nisha B. Nagarsheth Clear advanced filters

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

This Review details how chemokines shape immune responses in the tumour microenvironment through their effects on immune cells, stromal cells and the tumour cells themselves. The authors discuss the potential of targeting chemokine networks for cancer therapy.

Nisha Nagarsheth
Max S. Wicha
Weiping Zou
Reviews30 May 2017
Nature Reviews Immunology

Volume: 17, P: 559-572
TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

In a first-in-human phase 1 trial of patients with HPV-associated metastatic epithelial cancers, T cells targeting HPV-16 E7 were well tolerated, with one observed dose-limiting toxicity, and elicited objective clinical responses in 6 of 12 treated patients.

Nisha B. Nagarsheth
Scott M. Norberg
Christian S. Hinrichs
Research08 Feb 2021
Nature Medicine

Volume: 27, P: 419-425
Epigenetic silencing of T_H1-type chemokines shapes tumour immunity and immunotherapy

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Dongjun Peng
Ilona Kryczek
Weiping Zou
Research26 Oct 2015
Nature

Volume: 527, P: 249-253