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Showing 1–4 of 4 results
Advanced filters: Author: Niv Antonovsky Clear advanced filters

  • An E. coli strain able to use CO2 fixation for sugar synthesis was previously generated by experimental evolution of an engineered strain. Here, Herz et al. show that specific mutations in five genes, encoding carbon metabolism enzymes or key regulators, are sufficient to enable robust growth of the strain.

    • Elad Herz
    • Niv Antonovsky
    • Ron Milo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Soil microorganisms are a rich source of bioactive molecules. Here, the authors present a targeted sequencing workflow that reconstructs the clustered organization of biosynthetic domains in metagenomic libraries from amplicon data, thus guiding the discovery of novel metabolites from rare members of the soil microbiome.

    • Vincent Libis
    • Niv Antonovsky
    • Sean F. Brady
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Efficient mobilization and expression of biosynthetic gene clusters (BGCs) into heterologous hosts is needed for microbial natural products discovery. Here, the authors improve the CONKAT-seq strategy by simultaneously capturing the BCGs into a single large insert library and demonstrate its ability to discover natural products with new structures and potent antibacterial activity.

    • Vincent Libis
    • Logan W. MacIntyre
    • Sean F. Brady
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The basic axonal wiring of the vertebrate nervous system is set up during embryonic development, and during this process axons gain or lose sensitivity to guidance cues. Here the authors show that in proprioceptive axons, two members of the ADAM metalloproteinase family promote loss of responsiveness to Sema3A, via cleavage of its receptor Neuropilin-1.

    • Erez Romi
    • Irena Gokhman
    • Avraham Yaron
    Research
    Nature Communications
    Volume: 5, P: 1-15