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Showing 1–4 of 4 results
Advanced filters: Author: Noella Lopes Clear advanced filters

  • Natural killer cells can drive spreading cancer cells to enter a state of dormancy. That finding, together with the discovery of a pathway that hinders this antitumour function, could spur the development of new treatments.

    • Noella Lopes
    • Eric Vivier
    News & Views
    Nature
    Volume: 594, P: 501-502

  • γδ T cells have potent effector functions through their production of IFN-γ or IL-17. Pennington and colleagues demonstrate that IFN-γ+ γδ T and IL-17+ γδ T cells have distinct metabolic requirements that can be independently targeted to elicit specific immune responses.

    • Noella Lopes
    • Claire McIntyre
    • Lydia Lynch
    Research
    Nature Immunology
    Volume: 22, P: 179-192

  • Autoreactive T cells are removed during their development in the thymus through the functions of medullary thymic epithelial cells (mTEC) and dendritic cells (DC), a process termed negative selection. Here the authors show that mTEC-T cell crosstalk and lymphotoxin α signalling are essential for the proper recruitment of DCs into the thymus.

    • Noëlla Lopes
    • Jonathan Charaix
    • Magali Irla
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • This Review focuses on the roles of γδ T cells in tissue homeostasis and immune surveillance. The authors discuss exciting new studies showing how γδ T cells can regulate diverse physiological responses in tissues, ranging from thermogenesis in adipose tissue to remodelling at neuronal synapses.

    • Julie C. Ribot
    • Noëlla Lopes
    • Bruno Silva-Santos
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 221-232