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Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Ulrike Fiedler
Yvonne Reiss
Hellmut G Augustin
Research05 Feb 2006
Nature Medicine

Volume: 12, P: 235-239
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmonary cellular responses.

Geraldine Nouailles
Emanuel Wyler
Martin Witzenrath
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-18
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

A study of patients with COVID-19 and healthy donors found CD4⁺ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined.

Julian Braun
Lucie Loyal
Andreas Thiel
Research29 Jul 2020
Nature

Volume: 587, P: 270-274
Ultra-fast proteomics with Scanning SWATH

Scanning SWATH increases the speed and selectivity of proteomics.

Christoph B. Messner
Vadim Demichev
Markus Ralser
Research25 Mar 2021
Nature Biotechnology

Volume: 39, P: 846-854
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Elena Kostadinova
Catherine Chaput
Bastian Opitz
ResearchOpen Access01 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.

Robert Lorenz Chua
Soeren Lukassen
Roland Eils
Research26 Jun 2020
Nature Biotechnology

Volume: 38, P: 970-979
CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells

Some bacteria evade immune detection in the human respiratory tract. Slevogt and colleagues show that bacterial stimulation of the ITIM-containing CEACAM1 protein initiates signals that suppress TLR2-induced Akt activation and inflammation.

Hortense Slevogt
Solveig Zabel
Bernhard B Singer
Research05 Oct 2008
Nature Immunology

Volume: 9, P: 1270-1278
Recognition of microbial viability via TLR8 drives T_FH cell differentiation and vaccine responses

Sander and colleagues show that antigen-presenting cells detect bacterial RNA from live bacteria via TLR8 and promote T_FH cell differentiation and vaccine responses through the induction of a specific cytokine profile.

Matteo Ugolini
Jenny Gerhard
Leif E. Sander
Research19 Mar 2018
Nature Immunology

Volume: 19, P: 386-396
A biomathematical model of SARS-CoV-2 in Syrian hamsters

Sibylle Schirm
Geraldine Nouailles
Markus Scholz
ResearchOpen Access18 Dec 2024
Scientific Reports

Volume: 14, P: 1-18
Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

Ann-Kathrin Desch
Kristin Hartung
Andreas Bräuninger
Research20 Aug 2019
Leukemia

Volume: 34, P: 151-166
DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages

Toni Herta
Aritra Bhattacharyya
Janine Zahlten
ResearchOpen Access10 Apr 2018
Scientific Reports

Volume: 8, P: 1-14
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Morgan Essex
Belén Millet Pascual-Leone
Bastian Opitz
ResearchOpen Access01 Aug 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-15
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Wilhelm Bertrams
Katja Hönzke
Andreas C. Hocke
ResearchOpen Access29 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
Human alveolar progenitors generate dual lineage bronchioalveolar organoids

The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.

Karen Hoffmann
Benedikt Obermayer
Mirjana Kessler
ResearchOpen Access25 Aug 2022
Communications Biology

Volume: 5, P: 1-17
Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation

Wilhelm Bertrams
Kathrin Griss
Bernd Schmeck
ResearchOpen Access14 Jan 2020
Scientific Reports

Volume: 10, P: 1-9
Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

Andreas Nerlich
Maren Mieth
Andreas C. Hocke
ResearchOpen Access09 Jan 2018
Scientific Reports

Volume: 8, P: 1-13

Search

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Ultra-fast proteomics with Scanning SWATH

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells

Recognition of microbial viability via TLR8 drives T_FH cell differentiation and vaccine responses

A biomathematical model of SARS-CoV-2 in Syrian hamsters

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

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