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Showing 1–2 of 2 results
Advanced filters: Author: Norbert Tennagels Clear advanced filters

  • Human glucose transporters (GLUTs), particularly GLUT1 and GLUT3, are potential anticancer therapy targets. Here, Nan Wang et al. use an engineered GLUT 3 variant to identify an exofacial GLUT3 inhibitor, SA47, and elucidate the drug’s inhibitory mechanism.

    • Nan Wang
    • Shuo Zhang
    • Nieng Yan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that sheds light on the mechanism of signal transduction.

    • Felix Weis
    • John G. Menting
    • Michael C. Lawrence
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10