Where anticholinergic therapy fails for overactive bladder and detrusor overactivity, botulinum toxin can be an excellent alternative. Data on this therapy's mechanisms of action, optimum delivery techniques and indications are, however, still unclear. This Review discusses these issues, mainly in relation to neurogenic and idiopathic detrusor overactivity but also with new therapeutic directions in mind.
- Arun Sahai
- Mohammad S Khan
- Prokar Dasgupta
