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Stem cells

NORMAN ISCOVE
Research05 Sept 1991
Nature

Volume: 353, P: 26
Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques

Mamoru Watanabe
Keith A. Reimann
Norman L. Letvin
Research19 Jan 1989
Nature

Volume: 337, P: 267-270
Two distinct factors are required for induction of T-cell growth

Eva-Lotta Larsson
Norman N. Iscove
Antonio Coutinho
Research14 Feb 1980
Nature

Volume: 283, P: 664-666
Hematopoietic stem cells engraft in mice with absolute efficiency

Patricia Benveniste
Claude Cantin
Norman N. Iscove
Research25 May 2003
Nature Immunology

Volume: 4, P: 708-713
GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

Although GATA-3 is expressed in hematopoietic stem cells, its function there remains unclear. Iscove and colleagues show that GATA-3 inhibits the self-renewal potential of long-term hematopoietic stem cells downstream of p38 signaling.

Catherine Frelin
Robert Herrington
Norman N Iscove
Research25 Aug 2013
Nature Immunology

Volume: 14, P: 1037-1044
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils

Mature B cells express immunoglobulin D, but its function is unknown. Cerutti and colleagues show that respiratory mucosal B cells secrete immunoglobulin D, which activates basophils and enhances antimicrobial function.

Kang Chen
Weifeng Xu
Andrea Cerutti
Research28 Jun 2009
Nature Immunology

Volume: 10, P: 889-898
Microdroplet-based one-step RT-PCR for ultrahigh throughput single-cell multiplex gene expression analysis and rare cell detection

Jennifer Ma
Gary Tran
Peter W. Zandstra
ResearchOpen Access24 Mar 2021
Scientific Reports

Volume: 11, P: 1-18
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

Brigger et al. show that adipose tissue eosinophil dysfunction with age underpins physiological features of ageing, including global inflammation, loss of physical fitness and myeloid skewing. Eosinophils transferred from young to aged mice reversed these features and improved immunological fitness in old age, in part via IL-4.

Daniel Brigger
Carsten Riether
Alexander Eggel
Research06 Jul 2020
Nature Metabolism

Volume: 2, P: 688-702
Bipotential precursors of B cells and macrophages in murine fetal liver

Ana Cumano
Christopher J. Paige
Gerard Brady
Research16 Apr 1992
Nature

Volume: 356, P: 612-615
Searching for stem cells

Norman Iscove
News & Views13 Sept 1990
Nature

Volume: 347, P: 126-127
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

Conditional expression of the most common somatic gain-of-function Ezh2 mutation in mouse models of melanoma and lymphoma reveals insight into its cooperation with other oncogenic events and its effects on the epigenome.

George P Souroullas
William R Jeck
Norman E Sharpless
Research02 May 2016
Nature Medicine

Volume: 22, P: 632-640
Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations

Cindi M. Morshead
Patricia Benveniste
Derek van der Kooy
Research01 Mar 2002
Nature Medicine

Volume: 8, P: 268-273
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.

Sash Lopaticki
Annie S. P. Yang
Justin A. Boddey
ResearchOpen Access15 Sept 2017
Nature Communications

Volume: 8, P: 1-10
In vitro and in vivo expansion of hematopoietic stem cells

Guy Sauvageau
Norman N Iscove
R Keith Humphries
Reviews20 Sept 2004
Oncogene

Volume: 23, P: 7223-7232
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Junko Irie-Sasaki
Takehiko Sasaki
Josef M. Penninger
Research18 Jan 2001
Nature

Volume: 409, P: 349-354
Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA

Norman N. Iscove
Mary Barbara
Neil Winegarden
Research12 Aug 2002
Nature Biotechnology

Volume: 20, P: 940-943
Self-renewal as a therapeutic target in human colorectal cancer

Cancer stem cells are thought to be resistant to anticancer therapies and are able to repopulate tumors and sustain tumor growth. The authors establish BMI-1 as a crucial regulator of cancer cell stemness in colorectal tumors and develop a chemical inhibitor that targets cancer stem cell renewal by reducing the levels of BMI-1. This strategy affords antitumor effects in vitro and in vivo and may pave the way for the precise targeting of elusive cancer stem cells.

Antonija Kreso
Peter van Galen
Catherine A O'Brien
Research01 Dec 2013
Nature Medicine

Volume: 20, P: 29-36
cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP

Silva H Hanissian
Umar Akbar
Stephan W Morris
Research29 Apr 2004
Oncogene

Volume: 23, P: 3700-3707
Reply to “Hematopoietic potential of neural stem cells”

Cindi M. Morshead
Derek Van der Kooy
Norman N. Iscove
Correspondence01 Jun 2002
Nature Medicine

Volume: 8, P: 536-537
Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation

Rui Fei
Yu Fei
Xian-lu Zeng
Research01 Apr 2008
Acta Pharmacologica Sinica

Volume: 29, P: 499-506
Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer

Junlian Gu
Yang Li
Qing Sun
ResearchOpen Access08 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein

Y Shao
Y Liu
D Q Xu
Research13 Aug 2010
Cancer Gene Therapy

Volume: 17, P: 844-854
Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3

L Zhang
L Zhao
X Fang
Research02 Oct 2009
Cancer Gene Therapy

Volume: 17, P: 171-179

Search

Stem cells

Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques

Two distinct factors are required for induction of T-cell growth

Hematopoietic stem cells engraft in mice with absolute efficiency

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils

Microdroplet-based one-step RT-PCR for ultrahigh throughput single-cell multiplex gene expression analysis and rare cell detection

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

Bipotential precursors of B cells and macrophages in murine fetal liver

Searching for stem cells

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation

Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations

Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts

In vitro and in vivo expansion of hematopoietic stem cells

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

Representation is faithfully preserved in global cDNA amplified exponentially from sub-picogram quantities of mRNA

Self-renewal as a therapeutic target in human colorectal cancer

cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP

Reply to “Hematopoietic potential of neural stem cells”

Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation

Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer

Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein

Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3

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