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Showing 1–5 of 5 results
Advanced filters: Author: Ofir Hakim Clear advanced filters

  • A genome-wide analysis determines the contribution of DNA breaks and nuclear interactions to the formation of random versus recurrent translocations; whereas random translocations follow nuclear interaction profiles, the frequency of recurrent translocations is directly proportional to the amount of DNA damage at translocation partners.

    • Ofir Hakim
    • Wolfgang Resch
    • Rafael Casellas
    Research
    Nature
    Volume: 484, P: 69-74

  • 4C (chromosome conformation capture on chip) analyses using the clock-controlled Dbp gene as bait reveal the existence of circadian long-range interactions in mouse embryonic fibroblasts. The Dbp circadian interactome is dependent on a functional circadian clock and contains a number of clock-related DNA elements.

    • Lorena Aguilar-Arnal
    • Ofir Hakim
    • Paolo Sassone-Corsi
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1206-1213

  • Nuclear bodies can nucleate at sites of active transcription and are beneficial for efficient gene expression. Here, the authors show that Cajal bodies, a prominent type of nuclear body, contribute to genome organization with global effects on gene expression and RNA splicing fidelity.

    • Qiuyan Wang
    • Iain A. Sawyer
    • Miroslav Dundr
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-17

  • Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear. Here, the authors show that the pluripotency master regulator, OCT4, counteracts differentiation induced by MITF in mouse embryonic stem cells.

    • Danna Sheinboim
    • Itay Maza
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • By integrating transcriptome, regulatory element and chromosome topology profiles, Schwartz et al identify redistribution of p53 and CTCF genomic binding to be associated with transcriptional and phenotypical changes during Ras-induced transformation of mammary epithelial cells.

    • Michal Schwartz
    • Avital Sarusi Portugez
    • Ofir Hakim
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13