Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Ofra Yanuka Clear advanced filters

  • Genetic imprinting ensures monoallelic gene expression critical for normal embryonic development. Here the authors take advantage of human haploid parthenogenic embryonic stem cells lacking paternal alleles to identify, by genome-wide screening, factors involved in the regulation of imprinted genes.

    • Shiran Bar
    • Dan Vershkov
    • Nissim Benvenisty
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Nissim Benvenisty and colleagues use induced pluripotent stem cells (iPSCs) derived from individuals with Prader-Willi syndrome (PWS) to model PWS in vitro. By comparison to parthenogenetic human iPSCs, they find that the PWS-associated noncoding RNA IPW regulates maternally expressed genes at the DLK1-DIO3 imprinted region through its effect on H3K9me3 histone marks in that region.

    • Yonatan Stelzer
    • Ido Sagi
    • Nissim Benvenisty
    Research
    Nature Genetics
    Volume: 46, P: 551-557

  • Haploid human embryonic stem cells have been derived from haploid oocytes, the cells maintain a normal haploid karyotype as pluripotent cells and, unexpectedly, as differentiated cells — loss-of-function genetic screens previously performed with haploid embryonic stem cells in mice can now be performed in humans.

    • Ido Sagi
    • Gloryn Chia
    • Nissim Benvenisty
    Research
    Nature
    Volume: 532, P: 107-111

  • It has long been known that in mammals maternally and paternally inherited genes can be differentially expressed. By generating human parthenogenetic induced pluripotent stem cell lines, the expression of parentally inherited genes is now examined genome wide, uncovering novel imprinted non-coding RNAs and demonstrating the consequences of parthenogenesis on human development.

    • Yonatan Stelzer
    • Ofra Yanuka
    • Nissim Benvenisty
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 735-741