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Showing 1–2 of 2 results
Advanced filters: Author: Ola Epemolu Clear advanced filters

  • Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthetase, demonstrating on-target mechanism of action and efficacy in vivo.

    • Simon R. Green
    • Susan H. Davis
    • Laura A. T. Cleghorn
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, providing a selective route to probe hypoxic signalling.

    • Julianty Frost
    • Carles Galdeano
    • Alessio Ciulli
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12