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Showing 1–3 of 3 results
Advanced filters: Author: Olena Kis Clear advanced filters

  • The regulatory subunits (RI) of protein kinase A (PKA) form a disulfide bond in response to cellular hydrogen peroxide. Here the authors show that disulfide-activation of PKARIa regulates VEGF-induced angiogenesis in mice and may represent a new therapeutic target in diseases with abnormal angiogenesis.

    • Joseph R. Burgoyne
    • Olena Rudyk
    • Philip Eaton
    Research
    Nature Communications
    Volume: 6, P: 1-8

  • Genetic profiling of multiple myeloma requires painful bone marrow biopsies. Here, the authors develop an alternative non-invasive method for sequencing of five oncogenes in circulating cell-free DNA from myeloma patients, demonstrating 96% concordance with bone marrow tumour profiling results.

    • Olena Kis
    • Rayan Kaedbey
    • Trevor J. Pugh
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11