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Showing 1–2 of 2 results
Advanced filters: Author: Olga Ignatyeva Clear advanced filters

  • Francis Drobniewski and colleagues report the whole-genome sequencing of 1,000 Mycobacterium tuberculosis strains obtained prospectively from patients over a 2-year period in Samara, Russia, a region with a high incidence of multidrug-resistant (MDR) tuberculosis. They compare these strains to a diverse panel of strains isolated from across the UK and characterize the patterns of the emergence and evolution of drug resistance.

    • Nicola Casali
    • Vladyslav Nikolayevskyy
    • Francis Drobniewski
    Research
    Nature Genetics
    Volume: 46, P: 279-286

  • Sergey Nejentsev and colleagues identify intronic variants in ASAP1 that associate with susceptibility to tuberculosis. They show that ASAP1 is downregulated in dendritic cells infected with Mycobacterium tuberculosis, impairing their migration and matrix degradation abilities.

    • James Curtis
    • Yang Luo
    • Sergey Nejentsev
    Research
    Nature Genetics
    Volume: 47, P: 523-527