Multiple sclerosis (MS) is a disease with both inflammatory and neurodegenerative components. In this Review, the authors discuss the potential roles of epigenetic changes in modulating MS disease progression and mediating the effects of environmental risk factors. They also discuss current knowledge of the pathophysiology of MS, including immune cell differentiation and epigenetic changes in relapsing–remitting and progressive MS.
- Marcus W. Koch
- Luanne M. Metz
- Olga Kovalchuk