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Advanced filters: Author: Oliver Kamari-Bidkorpeh Clear advanced filters
  • Regiospecific cyclizations of reactive poly-β-keto intermediates are known to lead to the structural variability of aromatic products of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs), but questions about the process remain. The crystal structure and mutational studies of a dissected product template monodomain from PksA, the NR-PKS that initiates the biosynethesis of the hepatocarcinogen aflatoxin B1, are now presented.

    • Jason M. Crawford
    • Tyler P. Korman
    • Craig A. Townsend
    Research
    Nature
    Volume: 461, P: 1139-1143