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HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

Adoptive regulatory T cell (Treg) therapy holds promise for the treatment of a range of immunopathological conditions. Here the authors explore the HLA engineering of allogenic Treg products that avoid T cell and NK cell attack and maintain immunomodulatory function in a human skin-xenograft model.

Oliver McCallion
Weijie Du
Fadi Issa
ResearchOpen Access13 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Selective remodelling of the adipose niche in obesity and weight loss

An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problems caused by obesity.

Antonio M. A. Miranda
Liam McAllan
William R. Scott
ResearchOpen Access09 Jul 2025
Nature

Volume: 644, P: 769-779
Multiscale topology classifies cells in subcellular spatial transcriptomics

A method for topological automatic cell type classification across subcellular resolution spatial transcriptomic platforms is proposed, resolving cell type information and locating sparsely dispersed cells in human kidney and mouse kidney and brain.

Katherine Benjamin
Aneesha Bhandari
Katherine R. Bull
ResearchOpen Access19 Jun 2024
Nature

Volume: 630, P: 943-949
Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome

Stephen J. Ansley
Jose L. Badano
Nicholas Katsanis
Research21 Sept 2003
Nature

Volume: 425, P: 628-633

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HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model

Selective remodelling of the adipose niche in obesity and weight loss

Multiscale topology classifies cells in subcellular spatial transcriptomics

Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome

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