Nature Search

To stay, remain or leave: how verbal concepts as response options in political referendums such as the Brexit polls might bias voting outcomes

Liane Ströbel
Iring Koch
David Antons
ResearchOpen Access30 Nov 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-11
Bias in culture-independent assessments of microbial biodiversity in the global ocean

Ben Temperton
Anna Oliver
Jack Gilbert
ResearchOpen Access29 Jan 2009
Nature Precedings

P: 1
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Pancreatic tumors are frequently divided into basal and classical subtypes. Here, the authors use single cell sequencing to investigate organoids derived from pancreatic cancer tissue and find a hierarchy of distinct cell states, and classical and basal cells existing within the same tumor.

Teresa G. Krieger
Solange Le Blanc
Christian Conrad
ResearchOpen Access05 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

Tohru Kobayashi
Sanbao Ruan
Wei Zhang
Research01 Apr 1998
Oncogene

Volume: 16, P: 1587-1591
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

Immune checkpoint inhibitors have limited efficacy in tumors with lower mutational burden and non-permissive microenvironment. Here, the authors show that combining MEK inhibition with an agonist anti-CD40 immunostimulatory antibody improves antitumor treatment by inducing immunogenic changes in the tumor microenvironment.

Daniel Baumann
Tanja Hägele
Rienk Offringa
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-18
Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

Constanze Schneider
Thomas Oellerich
Jindrich Cinatl Jr
Amendments and Corrections06 Jun 2017
Nature Medicine

Volume: 23, P: 788
Clinical practice guidelines — what is the evidence?

In three practice guidelines from ASCO, experts provide evidence-based recommendations that address overarching clinical questions for the management of patients with pancreatic cancer. These guidelines offer improved strategies for interdisciplinary patient management and highlight the need for further research in several areas.

Oliver Strobel
Markus W. Büchler
News & Views17 Aug 2016
Nature Reviews Clinical Oncology

Volume: 13, P: 593-594
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

In acute myeloid leukemia, hypomethylating agents decitabine and azacytidine are used interchangeably. Here, the authors show that the major metabolite of decitabine, but not azacytidine, is subject to SAMHD1 inactivation, highlighting SAMHD1 as a potential biomarker and therapeutic target

Thomas Oellerich
Constanze Schneider
Jindrich Cinatl Jr.
ResearchOpen Access02 Aug 2019
Nature Communications

Volume: 10, P: 1-14
Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

Zhou et al. investigate the molecular events that follow neoadjuvant treatment in PDAC patients, explore signatures of heterogeneous response and persister phenotypes, identify a CYP3A link to resistance and suggest that it is useful in predicting response.

Xu Zhou
Jingyu An
Peter Bailey
ResearchOpen Access07 Sept 2023
Nature Cancer

Volume: 4, P: 1362-1381
FDG-PET is not useful in early pancreatic cancer diagnosis

Better tools for early detection and accurate staging of pancreatic cancer are needed. The role of ¹⁸F-fluorodeoxyglucose (FDG)-PET in this setting is controversial. The results of a large retrospective study analyzing the value of FDG-PET in the diagnosis of pancreatic ductal adenocarcinoma are discussed here.

Oliver Strobel
Markus W. Büchler
News & Views12 Mar 2013
Nature Reviews Gastroenterology & Hepatology

Volume: 10, P: 203-205
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Expression of HNF1A and KRT81 stratifies pancreatic ductal adenocarcinoma tumors into different subtypes, and expression of cytochrome P450 3A5 mediates basal and/or drug-induced therapy resistance in each subtype.

Elisa M Noll
Christian Eisen
Martin R Sprick
Research08 Feb 2016
Nature Medicine

Volume: 22, P: 278-287
Common germline variants within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors

Daniele Campa
Gabriele Capurso
Federico Canzian
ResearchOpen Access23 Dec 2016
Scientific Reports

Volume: 6, P: 1-6
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and cell cycle control.

Cornelia Jäkel
Frank Bergmann
Peter Schmezer
ResearchOpen Access06 Nov 2017
Nature Communications

Volume: 8, P: 1-10
MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Arora Bharti
Kulkarni Ajinkya
Klein Oliver
ResearchOpen Access23 Sept 2024
npj Imaging

Volume: 2, P: 1-12
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Alison Klein and colleagues report a genome-wide meta-analysis to identify loci associated with pancreatic cancer risk. They identify associated variants at 17q25.1, 3q29, 7p13 and 2p13.3.

Erica J Childs
Evelina Mocci
Alison P Klein
Research22 Jun 2015
Nature Genetics

Volume: 47, P: 911-916
Washboard and fluted terrains on Pluto as evidence for ancient glaciation

A network of parallel ridges on the northwestern border of Sputnik Planitia on Pluto are the traces of debris material deposited by a glaciation of icy nitrogen that happened early in Pluto’s history, and left there once the N₂ ice disappeared by sublimation.

Oliver L. White
Jeffrey M. Moore
Kimberly Ennico
Research12 Nov 2018
Nature Astronomy

Volume: 3, P: 62-68
Convection in a volatile nitrogen-ice-rich layer drives Pluto’s geological vigour

The volatile-ice-filled basin informally named Sputnik Planum is central to Pluto’s geological activity; this ice layer is organized into cells or polygons, and it is now shown that convective overturn in a several-kilometre-thick layer of solid nitrogen can explain both the presence of the cells and their great width.

William B. McKinnon
Francis Nimmo
K. E. Smith
Research01 Jun 2016
Nature

Volume: 534, P: 82-85
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

The therapeutic response of acute myeloid leukemia to the nucleoside analog Ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the active metabolite Ara-CTP.

Constanze Schneider
Thomas Oellerich
Jindrich Cinatl Jr
Research19 Dec 2016
Nature Medicine

Volume: 23, P: 250-255
Optimizing the outcomes of pancreatic cancer surgery

Successful surgical resection offers patients with pancreatic cancer the best chance of survival. However, many patients do not have surgically resectable disease. In this Review, the authors describe recent improvements in pancreatic cancer surgery, which have increased survival and also enabled more patients to undergo surgery.

Oliver Strobel
John Neoptolemos
Markus W. Büchler
Reviews19 Oct 2018
Nature Reviews Clinical Oncology

Volume: 16, P: 11-26
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

Li Liu
Shanshan Han
Ingrid Herr
ResearchOpen Access19 Dec 2022
Cell Death & Disease

Volume: 13, P: 1-15
C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms

Anna Nießen
Simon Schimmack
Oliver Strobel
ResearchOpen Access09 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival

Manuel Gentiluomo
Chiara Corradi
Gabriele Capurso
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-8
Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract

Burkhard Schütz
Anna-Lena Ruppert
Eberhard Weihe
ResearchOpen Access25 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

Xiaodong Zhou
Li Xie
Franco Fortunato
ResearchOpen Access19 Jun 2017
Cell Death Discovery

Volume: 3, P: 1-9
SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Beatrice Mohelnikova-Duchonova
Ondrej Strouhal
Pavel Soucek
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFβ and JNK/AP-1

Li Liu
Ewa Aleksandrowicz
Ingrid Herr
ResearchOpen Access05 Oct 2017
Cell Death & Disease

Volume: 8, P: e3064
The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

Jörg Kleeff
Eithne Costello
John P Neoptolemos
ResearchOpen Access01 Sept 2016
British Journal of Cancer

Volume: 115, P: 887-894

Search

To stay, remain or leave: how verbal concepts as response options in political referendums such as the Brexit polls might bias voting outcomes

Bias in culture-independent assessments of microbial biodiversity in the global ocean

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy

Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

Clinical practice guidelines — what is the evidence?

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC

FDG-PET is not useful in early pancreatic cancer diagnosis

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Common germline variants within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Washboard and fluted terrains on Pluto as evidence for ancient glaciation

Convection in a volatile nitrogen-ice-rich layer drives Pluto’s geological vigour

SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

Optimizing the outcomes of pancreatic cancer surgery

Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

C-reactive protein independently predicts survival in pancreatic neuroendocrine neoplasms

Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival

Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract

The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFβ and JNK/AP-1

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

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