Homeobox proteins Engrailed-1 (En1) and Engrailed-2 (En2) are transcription factors that direct midbrain cell specification during development. Here, the authors show that exogenous En1 and En2 protect against dopaminergic cell death in several rodent models of Parkinson's disease.
- Daniel Alvarez-Fischer
- Julia Fuchs
- Alain Prochiantz