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Showing 1–4 of 4 results
Advanced filters: Author: Olivier Baudoin Clear advanced filters

  • Acoustical tweezers can exert forces several orders of magnitude greater than optical tweezers but the absence of spatial selectivity and their limited resolution has prevented their use for many applications in microbiology. Here the authors perform spatially selective contactless manipulation and positioning of human cells.

    • Michael Baudoin
    • Jean-Louis Thomas
    • Alexis Vlandas
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • A simple and general enantioselective method for the synthesis of non-fused lower carbo[n]helicenes (n = 4–6) is reported. The helicene scaffold is constructed with high enantioselectivity by Pd0-catalysed C–H arylation with aryl bromides. A bifunctional ligand provides a precise chiral environment that allows fine control of the enantioselectivity.

    • Shu-Min Guo
    • Soohee Huh
    • Olivier Baudoin
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 872-880

  • Here the enantioselective lithiation of Boc-1,3-oxazinanes is reported. Transmetallation to zinc allows for regiodivergent functionalization at either C4 or C5 positions via a ligand-controlled Negishi coupling, and subsequent oxidative cleavage gives easy access to both β2- and β3-amino acids.

    • Weilong Lin
    • Ke-Feng Zhang
    • Olivier Baudoin
    Research
    Nature Catalysis
    Volume: 2, P: 882-888

  • Automated design and build processes can rapidly accelerate work in synthetic biology and metabolic engineering. Here the authors present Galaxy-SynBioCAD, a toolshed for synthetic biology, metabolic engineering, and industrial biotechnology that they use to build and execute Galaxy scientific workflows from pathway design to strain engineering through the automated generation of scripts driving robotic workstations.

    • Joan Hérisson
    • Thomas Duigou
    • Jean-Loup Faulon
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12