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Showing 1–10 of 10 results
Advanced filters: Author: Omer Dushek Clear advanced filters

  • There is currently no single model that fits the wealth of experimental data that relate T cell activation to T cell receptor–peptide–MHC binding parameters. Here, the authors analyse and reformulate the published models, and suggest that a kinetic proofreading model that involves limited T cell receptor signalling provides the best fit.

    • Melissa Lever
    • Philip K. Maini
    • Omer Dushek
    Research
    Nature Reviews Immunology
    Volume: 14, P: 619-629

  • Mucins on the surface of healthy T cells limit their phagocytic uptake by macrophages. Here the authors show that upon apoptosis induction in T cells, surface mucins are cleaved and released by ADAM10 to promote efferocytosis of the apoptotic cells.

    • Linnea Z. Drexhage
    • Shengpan Zhang
    • Quentin J. Sattentau
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.

    • Pablo F. Céspedes
    • Ashwin Jainarayanan
    • Michael L. Dustin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

    • Omer Dushek
    • Michael L. Dustin
    News & Views
    Nature Immunology
    Volume: 19, P: 1280-1281

  • Three main types of mechanism have been proposed to explain T cell receptor (TCR) triggering: aggregation, conformation change and segregation. The most recent data on these mechanisms are discussed here, and the authors propose an integrated model for TCR triggering.

    • P. Anton van der Merwe
    • Omer Dushek
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 47-55