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Showing 1–18 of 18 results
Advanced filters: Author: Omid C Farokhzad Clear advanced filters

  • Platelets delivering the immunotherapeutic antibody anti-PD-L1 to the site of surgically removed tumours reduce cancer recurrence and metastatic spread in mice.

    • Morteza Mahmoudi
    • Omid C. Farokhzad
    News & Views
    Nature Biomedical Engineering
    Volume: 1, P: 1-3

  • Polymeric nanomaterials have a rich history of applications in the selective delivery of small-molecule drugs to their biological targets. This Review discusses the evolution of drug delivery using such polymers and explores how these approaches have evolved in parallel with the ability to prepare ever more architecturally complex macromolecular structures.

    • Ashok Kakkar
    • Giovanni Traverso
    • Robert Langer
    Reviews
    Nature Reviews Chemistry
    Volume: 1, P: 1-17

  • Cloaking drug-loaded nanoparticles with platelet membranes enhances the drugs' abilities to target desired cells and tissues. This technology might improve treatments for cardiovascular and infectious diseases. See Letter p.118

    • Omid C. Farokhzad
    News & Views
    Nature
    Volume: 526, P: 47-48

  • This Review summarizes progress in applying nanotechnology to cancer treatment and discusses the challenges of clinical translation and opportunities to develop more effective nanotherapeutics through our increasing understanding of tumour biology and nano–bio interactions.

    • Jinjun Shi
    • Philip W. Kantoff
    • Omid C. Farokhzad
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 20-37

  • The use of nanoparticles has great potential for targeted delivery of therapeutics to specific cell types in the kidney. Here, the authors discuss the characteristics of nanoparticles and of renal physiology that must be considered when developing nanomedicines to treat kidney disease, as well as the remaining challenges in clinical translation of this technology.

    • Nazila Kamaly
    • John C. He
    • Omid C. Farokhzad
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 738-753

  • A balance between high stability and rapid degradation is required for effective photothermal anti-cancer agents. Here, the authors use Cu2+ to accelerate the degradation of black phosphorus nanosheets while enhancing its photothermal ability and apply this material for PET-guided, CDT-enhanced combination cancer therapy in mice.

    • Kuan Hu
    • Lin Xie
    • Ming-Rong Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The development of generic therapeutic nanoparticles faces a combination of scientific, patent and regulatory challenges.

    • Paul Burgess
    • Peter Barton Hutt
    • Stephen Zale
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 1267-1270

  • Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.

    • John E. Blume
    • William C. Manning
    • Omid C. Farokhzad
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Drug-loaded nanoparticles allow controlled release and enhanced delivery, yet understanding in vivobehavior has been difficult. Here, the authors develop a platinum prodrug coupled to a polymer platform, and use intravital imaging to show that the nanoparticle accumulates in macrophages, from the which drug redistributes to neighboring tumour cells.

    • Miles A. Miller
    • Yao-Rong Zheng
    • Ralph Weissleder
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Understanding the interaction between nanoparticles and biomolecules is crucial for improving current drug-delivery systems. Here, the authors shed light on the essential role of the surface and other physicochemical properties of a library of nanoparticles on their in vivo pharmacokinetics.

    • Nicolas Bertrand
    • Philippe Grenier
    • Omid C. Farokhzad
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Microfluidic technologies can tackle some of the challenges in translating nanoparticles to the clinic. This Progress Article outlines these advances and offers an assessment of the near- and long-term impact of microfluidic technologies in nanomedicine.

    • Pedro M. Valencia
    • Omid C. Farokhzad
    • Robert Langer
    Reviews
    Nature Nanotechnology
    Volume: 7, P: 623-629

  • Materials science provides tools and technologies for the protection against viral infections, as well as for the understanding, diagnosis, treatment and prevention of viral diseases. This Review discusses present and future directions in antiviral materials-science research, with a focus on COVID-19.

    • Zhongmin Tang
    • Na Kong
    • Wei Tao
    Reviews
    Nature Reviews Materials
    Volume: 5, P: 847-860

  • This review covers recent advances in nanoparticle and nanoscaffolding systems for the treatment of ischemic cardiomyopathy with emphasis on regenerative medicine, cell therapy and drug delivery technologies.

    • Morteza Mahmoudi
    • Mikyung Yu
    • Omid C. Farokhzad
    Reviews
    Nature Nanotechnology
    Volume: 12, P: 845-855