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Showing 1–4 of 4 results
Advanced filters: Author: Orlando B. Giorgetti Clear advanced filters

  • TCRα repertoire diversity is best explained by species-specific extents of sequence microhomologies marking the ends of recombining elements, and germline sequence composition of rearranging elements determines the degree of diversity of somatically generated antigen receptors.

    • Orlando B. Giorgetti
    • Connor P. O’Meara
    • Thomas Boehm
    ResearchOpen Access
    Nature
    Volume: 619, P: 193-200

  • O’Meara et al. utilize a panel of zebrafish mutants to perform a whole organism genetic interaction screen, examining the network regulating T cell differentiation. The authors use a T cell acute lymphoblastic leukemia (T-ALL) model to integrate the effects of small molecule inhibitors of the T cell differentiation pathway and establish a combination therapy for T-ALL in juvenile zebrafish.

    • Connor P. O’Meara
    • Lucia Guerri
    • Thomas Boehm
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-18

  • Thymic architecture and T cell repertoire analysis of a mouse model for thymoma and the role of the transcription factor GTF2I shows suitability of this model to recapitulate human thymomas and a severe effect of Gtf2i mutations on the medullary compartment.

    • Orlando B. Giorgetti
    • Anja Nusser
    • Thomas Boehm
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-12