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Showing 1–4 of 4 results
Advanced filters: Author: Orlando D. Schärer Clear advanced filters

  • The antitumor drug trabectedin is more toxic to DNA-repair-proficient cells. Here the authors show that this is caused by persistent DNA breaks induced from an abortive repair reaction and develop “TRABI-Seq” to map the breaks to transcribed regions of the genome. Trabectedin may thus be used as a diagnostic and therapeutic in precision oncology.

    • Kook Son
    • Vakil Takhaveev
    • Orlando D. Schärer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The DNA-repair machinery is faced with the significant challenge of differentiating DNA lesions from unmodified DNA. Two recent publications, one in this issue of Nature Structural & Molecular Biology, uncover a new way of recognizing minimally distorting DNA lesions: insertion of a 3- or 4-amino-acid wedge into DNA to extrude the lesion into a shallow binding pocket that can accommodate various damaged bases.

    • Orlando D Schärer
    • Arthur J Campbell
    News & Views
    Nature Structural & Molecular Biology
    Volume: 16, P: 102-104

  • The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and protecting stalled forks by regulating the replication fork protection complex (FPC).

    • Julie Rageul
    • Jennifer J. Park
    • Hyungjin Kim
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16