Nature Search

Thyroid Hormones in Human Milk and their Influence on Thyroid Function of Breast-Fed Babies

Hitoshi Mizuta
Nobuyuki Amino
Kiyoshi Miyai
Research01 Jun 1983
Pediatric Research

Volume: 17, P: 468-471
Semiautomated Enzyme Immunoassay of Thyrotropin as a Mass Screening Test for Neonatal Hypothyroidism

Kiyoshi Miyai
Tsuneo Tsuruhara
Toshiaki Oura
Research01 Dec 1984
Pediatric Research

Volume: 18, P: 1289-1292
Insights into G-protein coupling preference from cryo-EM structures of G_q-bound PTH1R

Description of the cryo-EM structures of the parathyroid hormone type 1 receptor associated with G_q reveals two distinct extracellular conformations with N-glycans stabilizing a ligand-tilted conformation.

Fumiya K. Sano
Kota Shimizume
Osamu Nureki
ResearchOpen Access26 Jun 2025
Nature Chemical Biology

P: 1-9
Effect of the Energy Source on Changes in Energy Expenditure, Respiratory Quotient, and Nitrogen Balance during Total Parenteral Nutrition in Children

Osamu Nose
James R Tipton
Hyakuji Yabuuchi
Research01 Jun 1987
Pediatric Research

Volume: 21, P: 538-541
Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhibition through further computational analysis and electrophysiology measurements.

Go Kasuya
Toshiaki Yamaura
Osamu Nureki
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Structural basis for lysophosphatidylserine recognition by GPR34

GPR34 is a GPCR which has an immunomodulatory role and recognizes lysophosphatidylserine (LysoPS) as a putative endogenous ligand. Here, authors report two cryo-EM structures of human GPR34-Gi complex with one of two ligands bound: either the LysoPS analogue S3E-LysoPS, or its derivative M1.

Tamaki Izume
Ryo Kawahara
Osamu Nureki
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Cryo-EM structure of the human MT₁–G_i signaling complex

A cryo-EM structure of the active human melatonin receptor in complex with G_i reveals conformational changes upon activation and the molecular basis for G-protein selectivity.

Hiroyuki H. Okamoto
Hirotake Miyauchi
Osamu Nureki
Research05 Aug 2021
Nature Structural & Molecular Biology

Volume: 28, P: 694-701
Structural insights into the mechanism of rhodopsin phosphodiesterase

Rhodopsin phosphodiesterase (Rh-PDE) hydrolyzes both cAMP and cGMP in a light-dependent manner. Structural and functional analyses of the Rh-PDE from Salpingoeca rosetta reveal unusual rhodopsin topology comprising 8 transmembrane helices (TMs) and suggest that TM0 plays a crucial role in the enzymatic photoactivity.

Tatsuya Ikuta
Wataru Shihoya
Osamu Nureki
ResearchOpen Access05 Nov 2020
Nature Communications

Volume: 11, P: 1-12
Structural basis of Sec-independent membrane protein insertion by YidC

The crystal structure of the bacterial protein YidC is reported, together with a structure-based functional analysis, providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane.

Kaoru Kumazaki
Shinobu Chiba
Osamu Nureki
Research16 Apr 2014
Nature

Volume: 509, P: 516-520
Class B1 GPCR activation by an intracellular agonist

A new intracellular agonist-binding pocket is identified that is common to many G protein-coupled receptors, which will have implications for the development of biased compounds that target this large group of receptors.

Kazuhiro Kobayashi
Kouki Kawakami
Osamu Nureki
ResearchOpen Access07 Jun 2023
Nature

Volume: 618, P: 1085-1093
Structural insights into tetraspanin CD9 function

Tetraspanins play critical roles in various physiological processes, ranging from cell adhesion to virus infection. Here authors report the crystal structure of CD9 and the cryo-electron microscopic structure of CD9 in complex with its single membrane-spanning partner protein, EWI-2.

Rie Umeda
Yuhkoh Satouh
Osamu Nureki
ResearchOpen Access30 Mar 2020
Nature Communications

Volume: 11, P: 1-11
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

Parental responsibilities in mice are usually carried out by the mother of the pups. In this study, the authors show that when mothers are separated from their mouse pups, they emit ultrasonic vocalizations to their male partners, who respond by administering paternal care to the pups.

Hong-Xiang Liu
Olga Lopatina
Haruhiro Higashida
ResearchOpen Access08 Jan 2013
Nature Communications

Volume: 4, P: 1-8
Hereditary hemorrhagic telangiectasia in Japanese patients

Masaki Komiyama
Tomoya Ishiguro
Takayuki Morisaki
Research07 Nov 2013
Journal of Human Genetics

Volume: 59, P: 37-41
1145 AMMONIA METABOLISM OF A PATIENT WITH ORNITHINE TRANSCARBAMYLASE DEFICIENCY DETECTED BY 15N TRACER METHOD

Hiroko Kodama
Osamu Nose
Albert B Sabin
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 633
Giant anisotropic thermal expansion actuated by thermodynamically assisted reorientation of imidazoliums in a single crystal

Designing materials with large thermal expansion is highly desirable to fabricate microscale devices. The authors report unusually large anisotropic negative and positive thermal expansion in a simple crystalline material, through temperature-driven orientation of imidazole cations acting as molecular wheels.

Zi-Shuo Yao
Hanxi Guan
Jun Tao
ResearchOpen Access22 Oct 2019
Nature Communications

Volume: 10, P: 1-8
Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

The first crystal structures of TPT, a membrane transporter that exports the Calvin cycle intermediates from chloroplasts and plays fundamental roles in nearly all photosynthetic eukaryotes, have now been resolved in complex with different substrates.

Yongchan Lee
Tomohiro Nishizawa
Osamu Nureki
Research02 Oct 2017
Nature Plants

Volume: 3, P: 825-832
Structural insights into ligand recognition and G protein preferences across histamine receptors

This study presents cryo-EM structures of H₄R–G_i and H₁R–G_i/G_s complexes, revealing distinct histamine recognition, activation mechanisms, and a critical determinant of G protein selectivity in H₁R and H₄R.

Yuma Matsuzaki
Fumiya K. Sano
Osamu Nureki
ResearchOpen Access27 Jun 2025
Communications Biology

Volume: 8, P: 1-15
A Highly Reversible Lithium Metal Anode

Min Sik Park
Sang Bok Ma
Osamu Yamamoto
ResearchOpen Access22 Jan 2014
Scientific Reports

Volume: 4, P: 1-8
Novel BCL11B truncation variant in a patient with developmental delay, distinctive features, and early craniosynostosis

Kaoru Eto
Osamu Machida
Toshiyuki Yamamoto
ResearchOpen Access05 Dec 2022
Human Genome Variation

Volume: 9, P: 1-5
Phenotype–genotype correlation in two patients with 12q proximal deletion

Noriko Miyake
Hidefumi Tonoki
Naomichi Matsumoto
Research01 May 2004
Journal of Human Genetics

Volume: 49, P: 282-284
Structural basis for amino acid export by DMT superfamily transporter YddG

The X-ray structure of the drug/metabolite transporter (DMT) protein YddG from Starkeya novella reveals a new membrane transport topology, with ten transmembrane segments in an outward-facing state and two pseudo-symmetric inverted structural repeats.

Hirotoshi Tsuchiya
Shintaro Doki
Osamu Nureki
Research30 May 2016
Nature

Volume: 534, P: 417-420
Intravesical nerve growth factor antisense therapy for bladder hypersensitivity induced by psychological stress

Tetsuichi Saito
Pradeep Tyagi
Naoki Yoshimura
Research03 Sept 2024
Gene Therapy

Volume: 31, P: 607-613
A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus

Kenta Inomata
Kazuki Tajima
Yuko Kitagawa
ResearchOpen Access09 Oct 2018
Scientific Reports

Volume: 8, P: 1-12
Genotype-phenotype correlation of 5p- syndrome: pitfall of diagnosis

Tatsuro Kondoh
Osamu Shimokawa
Hiroyuki Moriuchi
Research01 Jan 2005
Journal of Human Genetics

Volume: 50, P: 26-29
Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis

Nozomi Takahashi
Miyuki Harada
Yutaka Osuga
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Biodistribution of lentiviral transduced adipose-derived stem cells for “ex-vivo” regional gene therapy for bone repair

Jennifer A. Bell
Kevin Collon
Jay R. Lieberman
Research11 Aug 2023
Gene Therapy

Volume: 30, P: 826-834
Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate

Tetsuichi Saito
T. Kevin Hitchens
Pradeep Tyagi
ResearchOpen Access30 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Early visual processing relevant to the reduction of adaptation-induced perceptual bias

Tomokazu Urakawa
Motoyoshi Tanaka
Osamu Araki
ResearchOpen Access29 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
Topological pruning enables ultra-low Rayleigh scattering in pressure-quenched silica glass

Yongjian Yang
Osamu Homma
John C. Mauro
ResearchOpen Access17 Sept 2020
npj Computational Materials

Volume: 6, P: 1-8
Utility of real-time prospective motion correction (PROMO) on 3D T1-weighted imaging in automated brain structure measurements

Keita Watanabe
Shingo Kakeda
Yukunori Korogi
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
706 ADMINISTRATION OF LIPID IMPROVES NITROGEN RETENTION IN CH,LDREN RECEIVING ISOCALORIC TPN

Osamu Nose
Jams R Tipton
Marvin E Ament
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 228

Search

Thyroid Hormones in Human Milk and their Influence on Thyroid Function of Breast-Fed Babies

Semiautomated Enzyme Immunoassay of Thyrotropin as a Mass Screening Test for Neonatal Hypothyroidism

Insights into G-protein coupling preference from cryo-EM structures of G_q-bound PTH1R

Effect of the Energy Source on Changes in Energy Expenditure, Respiratory Quotient, and Nitrogen Balance during Total Parenteral Nutrition in Children

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

Structural basis for lysophosphatidylserine recognition by GPR34

Cryo-EM structure of the human MT₁–G_i signaling complex

Structural insights into the mechanism of rhodopsin phosphodiesterase

Structural basis of Sec-independent membrane protein insertion by YidC

Class B1 GPCR activation by an intracellular agonist

Structural insights into tetraspanin CD9 function

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

Hereditary hemorrhagic telangiectasia in Japanese patients

1145 AMMONIA METABOLISM OF A PATIENT WITH ORNITHINE TRANSCARBAMYLASE DEFICIENCY DETECTED BY 15N TRACER METHOD

Giant anisotropic thermal expansion actuated by thermodynamically assisted reorientation of imidazoliums in a single crystal

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

Structural insights into ligand recognition and G protein preferences across histamine receptors

A Highly Reversible Lithium Metal Anode

Novel BCL11B truncation variant in a patient with developmental delay, distinctive features, and early craniosynostosis

Phenotype–genotype correlation in two patients with 12q proximal deletion

Structural basis for amino acid export by DMT superfamily transporter YddG

Intravesical nerve growth factor antisense therapy for bladder hypersensitivity induced by psychological stress

A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus

Genotype-phenotype correlation of 5p- syndrome: pitfall of diagnosis

Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis

Biodistribution of lentiviral transduced adipose-derived stem cells for “ex-vivo” regional gene therapy for bone repair

Functional and histologic imaging of urinary bladder wall after exposure to psychological stress and protamine sulfate

Early visual processing relevant to the reduction of adaptation-induced perceptual bias

Topological pruning enables ultra-low Rayleigh scattering in pressure-quenched silica glass

Utility of real-time prospective motion correction (PROMO) on 3D T1-weighted imaging in automated brain structure measurements

706 ADMINISTRATION OF LIPID IMPROVES NITROGEN RETENTION IN CH,LDREN RECEIVING ISOCALORIC TPN

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