Nature Search

Crystallization of Recombinant Human Interleukin–2

Norihiko Moriya
Takao Yamada
Osamu Nishimura
Research01 Oct 1986
Bio/Technology

Volume: 4, P: 904-905
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5

Augmented AMP-activated protein kinase (AMPK) activity inhibits cell migration through an unknown mechanism. Here, Yan et al.show that AMPK phosphorylates the novel substrate PDZ and LIM domain 5 (Pdlim5), and that phosphomimetic Pdlim5 impairs cell migration by disrupting the Rac1-Arp2/3 signalling pathway.

Yi Yan
Osamu Tsukamoto
Seiji Takashima
ResearchOpen Access30 Jan 2015
Nature Communications

Volume: 6, P: 1-14
Enzymatic Cleavage of Amino Terminal Methionine from Recombinant Human Interleukin 2 and Growth Hormone by Aminopeptidase M

Shizue Nakagawa
Takao Yamada
Osamu Nishimura
Research01 Aug 1987
Bio/Technology

Volume: 5, P: 824-827
Phototrophy by antenna-containing rhodopsin pumps in aquatic environments

Light energy transfer from abundant hydroxylated carotenoids to the retinal moiety of widespread light-driven proton pumps is detected.

Ariel Chazan
Ishita Das
Oded Béjà
Research01 Mar 2023
Nature

Volume: 615, P: 535-540
Plasma indoxyl sulfate levels predict cardiovascular events in patients with mild chronic heart failure

Miki Imazu
Hiroki Fukuda
Masafumi Kitakaze
ResearchOpen Access05 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
Structural insights into the nucleotide base specificity of P2X receptors

Go Kasuya
Yuichiro Fujiwara
Osamu Nureki
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
ORP150 protects against hypoxia/ischemia-induced neuronal death

Michio Tamatani
Tomohiro Matsuyama
Masaya Tohyama
Research01 Mar 2001
Nature Medicine

Volume: 7, P: 317-323
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Identification of CLEC10A as a human lectin for pancreatic ductal adenocarcinoma

Shuntaro Tsukamoto
Hiroaki Tateno
Tatsuya Oda
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-11
A prolactin-releasing peptide in the brain

Shuji Hinuma
Yugo Habata
Masahiko Fujino
Research21 May 1998
Nature

Volume: 393, P: 272-276
Angiotensin II Type 1 Receptor Blocker Prevents Atrial Structural Remodeling in Rats with Hypertension Induced by Chronic Nitric Oxide Inhibition

Hidetoshi Okazaki
Tetsuo Minamino
Masafumi Kitakaze
Research01 Apr 2006
Hypertension Research

Volume: 29, P: 277-284
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Age and Organ Dependent Spontaneous Generation of Nuclear 8-Hydroxydeoxyguanosine in Male Fischer 344 Rats

Dai Nakae
Hiroyuki Akai
Yoichi Konishi
Research01 Feb 2000
Laboratory Investigation

Volume: 80, P: 249-261
Considerable scatter in the relationship between left atrial volume and pressure in heart failure with preserved left ventricular ejection fraction

Shiro Hoshida
Tetsuya Watanabe
Yasushi Matsumura
ResearchOpen Access09 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Genetic and transcriptional landscape of plasma cells in POEMS syndrome

Yuhei Nagao
Naoya Mimura
Chiaki Nakaseko
Research11 Jan 2019
Leukemia

Volume: 33, P: 1723-1735
Long-term biopersistence of tangled oxidized carbon nanotubes inside and outside macrophages in rat subcutaneous tissue

Yoshinori Sato
Atsuro Yokoyama
Kazuyuki Tohji
ResearchOpen Access28 Aug 2013
Scientific Reports

Volume: 3, P: 1-10
Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA

Yuki Masumura
Shuichiro Higo
Yasushi Sakata
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14

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