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Advanced filters: Author: Ovidiu C. Andronesi Clear advanced filters

Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1) entered recently clinical trials for treatment of gliomas. Here, the authors apply a MRS imaging method for 2HG detection and assessement of the pharmacodynamic effects of the mutant IDH1 inhibitor (IDH305) in 8 mutant IDH1 glioma patients.

Ovidiu C. Andronesi
Isabel C. Arrillaga-Romany
Tracy T. Batchelor
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-9
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival

Ovidiu C. Andronesi
Morteza Esmaeili
Tracy T. Batchelor
ResearchOpen Access12 Jun 2017
npj Precision Oncology

Volume: 1, P: 1-9
An integrated RF-receive/B₀-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T

Morteza Esmaeili
Jason Stockmann
Ovidiu C. Andronesi
ResearchOpen Access14 Sept 2020
Scientific Reports

Volume: 10, P: 1-17

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